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陈兴珍

作者:陈兴珍 时间:2022-05-31 浏览次数:

职称:教授、博士生导师

学历:博士

E-mail:tangjingfeng@hbut.edu.cn

研究方向:1)膜蛋白电生理及离子通道;2)肿瘤发生机制及靶向药物;

基本信息:

陈兴珍,湖北工业大学教授、博士生导师,湖北省相关人才计划获得者。加拿大阿尔伯塔(Alberta)大学医bob电子游戏终身教授/博导。国际膜蛋白疾病及分子医学研究领域权威专家,国际膜蛋白与健康和疾。–SMB)委员会副主席。国际上报道TRPP3蛋白具有离子通道功能的第一人。1978考入浙江大学计算机系,1991-1997加拿大蒙特利尔(Montréal)大学物理学博士,1997-2000美国哈佛大学医bob电子游戏博士后,研究助理教授。加拿大国立卫生研究院(CIHR)、阿尔伯塔医学研究基金会(AHFMR)、加拿大肾脏病基金会(KFC)、美国国立卫生院(NIH)、美国国防部医学研究计划(CDMRP)基金评审专家。以第一作者或通讯作者在Nature, Nature Protocols, J Clin Inv, PNAS, Hum Mol Genet, FASEB J, JBC等著名杂志发表论文120余篇。总引用次数超过6,300次,单篇引用超过500次(Nature, 1999)。近年来获得科研项目30余项。担任Nature, PNAS, Hum Mol Genet, BBA, JASN,Biophys J, JBC等著名杂志审稿人。

科研成果:

(1)科研项目:

1. 国家自然基金面上项目:PKD2的S4-S5连接域与C末端间相互作用介导的调控其离子通道功能及相关疾病的机制,31871176,2019-2022

2. 国家自然基金面上项目:FUBP1对PKD2蛋白表达的调控及其在遗传性多囊肾发展的作用,主持,81570648,2016-2019。

3. 武汉光谷3551人才计划:急性肾脏损伤早期诊断系列免疫检测试剂的研发,主持,2018-2021。

4. 湖北工业大学科研启动经费:FUBP1对PKD2蛋白表达的调控机制及ADPKD治疗性抑制短肽的筛选研究,主持,2015-2019。

论文:

1. Chen, X.-Z., Vassilev, P.M., Basora, N., Peng, J.-B., Nomura, H., Segal, Y., Brown, E.M., Reeders, S.T., Hediger, M.A., and Zhou, J. Polycystin-L is a calcium-regulated cation channel permeable to calcium ions. Nature 401, 383-386, 1999.

2. Tsukaguchi, H., Tokui, T., Mackenzie, B., Berger, U.V.,Chen, X.-Z., Wang, Y.-X., Brubaker, R.F., and Hediger, M.A. A family of mammalian Na+-dependent L-ascorbic acid transporters. Nature 399, 7075, 1999.

3. Wu, Y., Li, Q., andChen, X.-Z.* Detecting protein-protein interactions by Far Western blotting. Nature Protocols. 2, 3278-3284, 2008.

4. Wu, Y., Dai, X.-Q., Li, Q., Chen, C.X., Mai, W., Hussain, Z., Long, W., Montalbetti, N., Li, G., Glynne, R., Wang, S., Cantiello, H.F., Wu, G., andChen, X.-Z.* Kinesin-2 mediates physical and functional interactions between polycystin-2 and fibrocystin. Hum. Mol. Genet. 15, 3280-3292, 2006.

5. Liang, G., Yang, J., Wang, Z., Li, Q., Tang, Y., andChen, X.-Z.* Polycystin-2 down-regulates cell proliferation via promoting PERK-dependent phosphorylation of eIF2α. Hum. Mol. Genet. 17, 3254-3262, 2009.

6. Liang, G., Li, Q., Tang, Y., Kokame, K., Kikuchi, T., Wu, G., andChen, X.-Z.*Polycystin-2 is regulated by endoplasmic reticulum-associated degradation. Hum. Mol. Genet. 17, 1109-1119, 2009.

7. Zheng, W., Shen, F., Hu, R., Roy, B., Yang, J., Wang, Q., Zhang, F., King, J.C., Sergi, C., Liu, S.-M., Cordat, E., Tang, J., Cao, Y., Ali, D.W., andChen, X.-Z.*Far upstream element-binding protein 1 binds the untranslated region of PKD2 and suppresses its translation. J. Am. Soc. Nephrol. 27, 2645-2657, 2016.

8. Zheng, W., Yang, J., Beauchamp, E., Cai, R., Hussein, S., Hofmann, L., Li, Q., Flockerzi, V., Berthiaume, L.G., Tang, J., andChen, X.-Z.* Regulation of TRPP3 channel function by N-terminal domain palmitoylation and phosphorylation. J. Biol. Chem. 291, 25678-25691, 2016.

9. Zheng, W., Hussein, S., Yang, J., Huang, J., Zhang, F., Hernandez-Anzaldo, S., Fernandez-Patron, C., Cao, Y., Zeng, H., Tang, J., and Chen, X.-Z.* A novel PKD2L1 C-terminal domain critical for trimerization and channel function. Scientific Rep. 5, 9460, 2015. DOI: 10.1038/srep09460.

10. Wang, Q., Cantero, M.R., Zheng, W., Wang, Z., Yang, J., Hussein, S., Cantiello, H.F., Tang, J., andChen, X.-Z.* Filamin-A increases the stability and plasma membrane expression of polycystin-2. PLOS One. 10, e0123018, 2015. DOI: 10.1371/journal.pone.0123018.

11. Long, W., Panwar, P., Witkowska, K., Wong, K., O'Neill, D.,Chen, X.-Z., Lemieux, M.J., and Cheeseman, C.I. Critical Roles of Two Hydrophobic Residues within Human Glucose Transporter 9 (hSLC2A9) in Substrate Selectivity and Urate Transport. J. Biol. Chem. In press, 2015.

12. Hu, Q., Wu, Y., Tang, J., Zheng, W., Wang, Q., Jing, X., Li, Q., Duszyk, M., Wang, S., Tu. J.-C. , andChen, X.-Z.* Expression of polycystins and fibrocystin on primary cilia of lung cells. Biochem. Cell Biol. 92, 547-54, 2014.

13. Wu, S.Y., Yu, M.X., Li, X.G., Xu, S.F., Shen, J., Sun, Z., Zhou, X.,Chen, X.-Z., and Tu, J.C. Identification of Homer1 as a potential prognostic marker for intrahepatic cholangiocarcinoma. Asian Pac J Cancer Prev. 15, 3299-304, 2014.

14. Yang, J., Zheng, W., Wang, Q., Lara, C., Hussein, S., andChen, X.-Z.* Translational up-regulation of polycystic kidney disease protein PKD2 by endoplasmic reticulum stress. FASEB J. 27, 4998-5009, 2013.

15. Wang, Q., Dai, X.-Q., Li, Q., Tuli, J., Liang, G., Li, S., andChen, X.-Z.*Filamin interacts with ENaC and inhibits its channel function. J. Biol. Chem. 288, 264-273, 2013.

16. Wang, Q., Dai, X.-Q., Wang, Z., Li, Q., Cantero, M.R., Li, S., Shen, J., Tu, J.-C., Cantiello, H.F. andChen, X.-Z.*Structural interaction and functional regulation of polycystin-2 by filamin. PLoS ONE. 7, e40448, 2012.

17. Yang, J., Wang, Q., Zheng, W., Tuli, J., Li, Q., Wu, Y., Hussein, S., Dai, X.-Q., Shafiei, S., Li, X.-G., Shen, P.Y., Tu, J.-C., andChen, X.-Z.*Receptor for activated C kinase 1 (RACK1) inhibits the function of TRP-type channel Pkd2L1 through physical interaction. J. Biol. Chem. 287, 6551-6561, 2012.

18. Yu, Y., Ulbrich, M.H., Li, M.-H., Buraei, Z.,Chen, X.-Z.,Ong, A.C.M., Tong, L., Isacoff, E.Y., and Yang, J. Structural and molecular basis of the assembly of the TRPP2/PKD1 complex. Proc. Natl. Acad. Sci. 106, 11558-11563, 2009.

19. Raychowdhury, M., Ramos, A., Zhang, P., McLaughin, M., Dai, X.-Q.,Chen, X.-Z., Montalbetti, N., Cantero, M.D.R., Ausiello, D., and Cantiello, H.F. Vasopressin receptor-mediated functional signaling pathway in primary cilia of renal epithelial cells. Am. J. Physiol. Renal Physiol. 296, F87-F97, 2009.

20. Liang, G., Yang, J., Wang, Z., Li, Q., Tang, Y., andChen, X.-Z.*Polycystin-2 down-regulates cell proliferation via promoting PERK-dependent phosphorylation of eIF2α. Hum. Mol. Genet. 17, 3254-3262, 2008.

21. Liang, G., Li, Q., Tang, Y., Kokame, K., Kikuchi, T., Wu, G., and Chen, X.-Z.* Polycystin-2 is regulated by endoplasmic reticulum-associated degradation. Hum. Mol. Genet. 17, 1109-1119, 2008.

22. Chen, X.-Z.*, Li, Q., Wu, Y., Liang, G., Lara, C.J., and Cantiello, H.F. Interaction of TRPP2 with the cell cytoskeleton. FEBS J. 275, 4675-4683, 2008.

23. Kim, I., Li, C., Liang, D.,Chen, X.-Z.,Coffy, R.J., Ma, J., Zhao, P., and Wu, G. Polycystin-2 expression is regulated by a PC2-binding domain in the intracellular portion of fibrocystin. J. Biol. Chem. 283, 31559-31566,

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